Reduction in Acute Filariasis Morbidity during a Mass Drug Administration Trial to Eliminate Lymphatic Filariasis in Papua New Guinea
Identifieur interne : 004B89 ( Main/Exploration ); précédent : 004B88; suivant : 004B90Reduction in Acute Filariasis Morbidity during a Mass Drug Administration Trial to Eliminate Lymphatic Filariasis in Papua New Guinea
Auteurs : Daniel J. Tisch [États-Unis] ; Neal D. E. Alexander [Papouasie-Nouvelle-Guinée, Royaume-Uni] ; Benson Kiniboro [Papouasie-Nouvelle-Guinée] ; Henry Dagoro [Papouasie-Nouvelle-Guinée] ; Peter M. Siba [Papouasie-Nouvelle-Guinée] ; Moses J. Bockarie [Papouasie-Nouvelle-Guinée, Royaume-Uni] ; Michael P. Alpers [Papouasie-Nouvelle-Guinée, Australie] ; James W. Kazura [États-Unis]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Filaricides (administration et posologie), Filariose lymphatique (), Filariose lymphatique (diagnostic), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Incidence, Jeune adulte, Membres (anatomopathologie), Mâle, Papouasie - Nouvelle-Guinée (épidémiologie), Région mammaire (anatomopathologie), Scrotum (anatomopathologie), Wuchereria bancrofti ().
- MESH :
- administration et posologie : Filaricides.
- anatomopathologie : Membres, Région mammaire, Scrotum.
- diagnostic : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Papouasie - Nouvelle-Guinée.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Incidence, Jeune adulte, Mâle, Wuchereria bancrofti.
- Wicri :
- geographic : Papouasie-Nouvelle-Guinée.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Breast (pathology), Child, Child, Preschool, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Extremities (pathology), Female, Filaricides (administration & dosage), Humans, Incidence, Male, Middle Aged, Papua New Guinea (epidemiology), Scrotum (pathology), Wuchereria bancrofti (drug effects), Young Adult.
- MESH :
- chemical , administration & dosage : Filaricides.
- geographic , epidemiology : Papua New Guinea.
- diagnosis : Elephantiasis, Filarial.
- drug effects : Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- pathology : Breast, Extremities, Scrotum.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Child, Preschool, Female, Humans, Incidence, Male, Middle Aged, Young Adult.
Abstract
Acute painful swelling of the extremities and scrotum are debilitating clinical manifestations of
Weekly active surveillance for acute filariasis morbidity defined by painful swelling of the extremities, scrotum and breast was performed 1 year before and each year after 4 annual mass administrations of anti-filarial drugs (16,480 person-years of observation). Acute morbidity events lasted <3 weeks in 92% of affected individuals and primarily involved the leg (74–79% of all annual events). The incidence for all communities considered together decreased from 0.39 per person-year in the pre-treatment year to 0.31, 0.15, 0.19 and 0.20 after each of 4 annual treatments (p<0.0001). Residents of communities with high pre-treatment transmission intensities (224–742 infective bites/person/year) experienced a greater reduction in acute morbidity (0.62 episodes per person-year pre-treatment vs. 0.30 in the 4th post-treatment year) than residents of communities with moderate pre-treatment transmission intensities (24–167 infective bites/person/year; 0.28 episodes per person-year pre-treatment vs. 0.16 in the 4th post-treatment year).
Mass administration of anti-filarial drugs results in immediate health benefit by decreasing the incidence of acute attacks of leg and arm swelling in people with pre-existing infection. Reduction in acute filariasis morbidity parallels decreased transmission intensity, suggesting that continuing exposure to infective mosquitoes is involved in the pathogenesis of acute filariasis morbidity.
Url:
DOI: 10.1371/journal.pntd.0001241
PubMed: 21765964
PubMed Central: 3134431
Affiliations:
- Australie, Papouasie-Nouvelle-Guinée, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Ohio
- Londres
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Le document en format XML
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Siba</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea</addr-line></nlm:aff><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation></author><author><name sortKey="Bockarie, Moses J" sort="Bockarie, Moses J" uniqKey="Bockarie M" first="Moses J." last="Bockarie">Moses J. Bockarie</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea</addr-line></nlm:aff><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Liverpool School of Tropical Medicine, Liverpool, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Alpers, Michael P" sort="Alpers, Michael P" uniqKey="Alpers M" first="Michael P." last="Alpers">Michael P. Alpers</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea</addr-line></nlm:aff><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Curtin University, Perth, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Curtin University, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Kazura, James W" sort="Kazura, James W" uniqKey="Kazura J" first="James W." last="Kazura">James W. Kazura</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Case Western Reserve University, Cleveland, Ohio, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve University, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Breast (pathology)</term><term>Child</term><term>Child, Preschool</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Extremities (pathology)</term><term>Female</term><term>Filaricides (administration & dosage)</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Papua New Guinea (epidemiology)</term><term>Scrotum (pathology)</term><term>Wuchereria bancrofti (drug effects)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filaricides (administration et posologie)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Membres (anatomopathologie)</term><term>Mâle</term><term>Papouasie - Nouvelle-Guinée (épidémiologie)</term><term>Région mammaire (anatomopathologie)</term><term>Scrotum (anatomopathologie)</term><term>Wuchereria bancrofti ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Membres</term><term>Région mammaire</term><term>Scrotum</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast</term><term>Extremities</term><term>Scrotum</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Papouasie - Nouvelle-Guinée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mâle</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Acute painful swelling of the extremities and scrotum are debilitating clinical manifestations of <italic>Wuchereria bancrofti</italic> infection. The ongoing global program to eliminate filariasis using mass drug administration is expected to decrease this and other forms of filarial morbidity in the future by preventing establishment of new infections as a consequence of eliminating transmission by the mosquito vector. We examined whether mass treatment with anti-filarial drugs has a more immediate health benefit by monitoring acute filariasis morbidity in Papua New Guinean communities that participated in a 5-year mass drug administration trial.</p></sec><sec><title>Methodology/Principal Findings</title><p>Weekly active surveillance for acute filariasis morbidity defined by painful swelling of the extremities, scrotum and breast was performed 1 year before and each year after 4 annual mass administrations of anti-filarial drugs (16,480 person-years of observation). Acute morbidity events lasted <3 weeks in 92% of affected individuals and primarily involved the leg (74–79% of all annual events). The incidence for all communities considered together decreased from 0.39 per person-year in the pre-treatment year to 0.31, 0.15, 0.19 and 0.20 after each of 4 annual treatments (p<0.0001). Residents of communities with high pre-treatment transmission intensities (224–742 infective bites/person/year) experienced a greater reduction in acute morbidity (0.62 episodes per person-year pre-treatment vs. 0.30 in the 4<sup>th</sup> post-treatment year) than residents of communities with moderate pre-treatment transmission intensities (24–167 infective bites/person/year; 0.28 episodes per person-year pre-treatment vs. 0.16 in the 4<sup>th</sup> post-treatment year).</p></sec><sec><title>Conclusions</title><p>Mass administration of anti-filarial drugs results in immediate health benefit by decreasing the incidence of acute attacks of leg and arm swelling in people with pre-existing infection. Reduction in acute filariasis morbidity parallels decreased transmission intensity, suggesting that continuing exposure to infective mosquitoes is involved in the pathogenesis of acute filariasis morbidity.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ramzy, Rm" uniqKey="Ramzy R">RM Ramzy</name></author><author><name sortKey="El Setouhy, M" uniqKey="El Setouhy M">M El Setouhy</name></author><author><name sortKey="Helmy, H" uniqKey="Helmy H">H Helmy</name></author><author><name sortKey="Ahmed, Es" uniqKey="Ahmed E">ES Ahmed</name></author><author><name sortKey="Abd Elaziz, Km" uniqKey="Abd Elaziz K">KM Abd Elaziz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tisch, Dj" uniqKey="Tisch D">DJ Tisch</name></author><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author><author><name sortKey="Dimber, Z" uniqKey="Dimber Z">Z Dimber</name></author><author><name sortKey="Kiniboro, B" uniqKey="Kiniboro B">B Kiniboro</name></author><author><name sortKey="Tarongka, N" uniqKey="Tarongka N">N Tarongka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author><author><name sortKey="Tisch, Dj" uniqKey="Tisch D">DJ Tisch</name></author><author><name sortKey="Kastens, W" uniqKey="Kastens W">W Kastens</name></author><author><name sortKey="Alexander, Nd" uniqKey="Alexander N">ND Alexander</name></author><author><name sortKey="Dimber, Z" uniqKey="Dimber Z">Z Dimber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcpherson, T" uniqKey="Mcpherson T">T McPherson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narahari, Sr" uniqKey="Narahari S">SR Narahari</name></author><author><name sortKey="Ryan, Tj" uniqKey="Ryan T">TJ Ryan</name></author><author><name sortKey="Mahadevan, Pe" uniqKey="Mahadevan 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Nayak</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Papouasie-Nouvelle-Guinée</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Ohio</li></region><settlement><li>Londres</li></settlement></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Tisch, Daniel J" sort="Tisch, Daniel J" uniqKey="Tisch D" first="Daniel J." last="Tisch">Daniel J. Tisch</name></region><name sortKey="Kazura, James W" sort="Kazura, James W" uniqKey="Kazura J" first="James W." last="Kazura">James W. Kazura</name></country><country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Alexander, Neal D E" sort="Alexander, Neal D E" uniqKey="Alexander N" first="Neal D. E." last="Alexander">Neal D. E. Alexander</name></noRegion><name sortKey="Alpers, Michael P" sort="Alpers, Michael P" uniqKey="Alpers M" first="Michael P." last="Alpers">Michael P. Alpers</name><name sortKey="Bockarie, Moses J" sort="Bockarie, Moses J" uniqKey="Bockarie M" first="Moses J." last="Bockarie">Moses J. Bockarie</name><name sortKey="Dagoro, Henry" sort="Dagoro, Henry" uniqKey="Dagoro H" first="Henry" last="Dagoro">Henry Dagoro</name><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name><name sortKey="Siba, Peter M" sort="Siba, Peter M" uniqKey="Siba P" first="Peter M." last="Siba">Peter M. Siba</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Alexander, Neal D E" sort="Alexander, Neal D E" uniqKey="Alexander N" first="Neal D. E." last="Alexander">Neal D. E. Alexander</name></region><name sortKey="Bockarie, Moses J" sort="Bockarie, Moses J" uniqKey="Bockarie M" first="Moses J." last="Bockarie">Moses J. Bockarie</name></country><country name="Australie"><noRegion><name sortKey="Alpers, Michael P" sort="Alpers, Michael P" uniqKey="Alpers M" first="Michael P." last="Alpers">Michael P. Alpers</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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